Variations in vascular mortality trends: Translational perspective

B.J. Cairns, A. Balkwill, D. Canoy, J. Green, G.K. Reeves, and V. Beral, for the Million Women Study Collaborators (2015). Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease. European Journal of Preventive Cardiology (online first). dx.doi.org/10.1177/2047487314563710

Translational perspective

One of the most striking health achievements of recent decades is the large fall in mortality from vascular diseases, particularly coronary heart disease, but there are signs that this trend may be slowing in some populations.

Despite the knowledge that within populations there is great variation in vascular disease risk factors, there has been limited research into whether, within populations, all groups have benefitted equally from the fall in vascular mortality.

We found evidence that the decline in vascular mortality from 2001-2010 was not uniform across all groups of UK women, including that coronary heart disease mortality declined by nearly three quarters in normal weight women, but only one quarter in obese women.

Continuing reductions in vascular mortality might be achieved by public health or clinical interventions that are better-targeted to the groups which previously have benefitted the least.


EJPC is a European Society for Cardiology journal, and this paper found a home there after being transferred from ESC’s flagship European Heart Journal.  

EHJ includes a “Translational Perspective” with many of its articles, and I wrote one for this study, but EJPC doesn’t do them.  Not to let that effort go to waste, I’ve published it here.

Comment: Cancer and high body-mass index

My commentary discussing the article, “Global burden of cancer attributable to high body-mass index in 2012: a population-based study” by Arnold and colleagues has just been published on The Lancet Oncology website:

Cairns BJ. Cancer and high body-mass index: global burden, global effort? Lancet Oncol 2014; Online First, 26 November 2014.

From the press release:

Writing in a linked Comment, Dr Benjamin Cairns from the University of Oxford in the UK says, “If 3·6% of all cancers are associated with high BMI, that is nearly half a million cancers, but this number is large mainly because the world population is large. Global health resources specifically for cancer prevention are not so large, and the resources targeted at obesity must be balanced against those for other important causes of cancer, particularly infections and tobacco use, which are each associated with much larger proportions of cases.”

I hope I’ll be able to post a paywall-free version of the full comment later. [UPDATE: This link might work.]  Until then, access is via the Lancet Oncology website: