Variations in vascular mortality trends: Translational perspective

B.J. Cairns, A. Balkwill, D. Canoy, J. Green, G.K. Reeves, and V. Beral, for the Million Women Study Collaborators (2015). Variations in vascular mortality trends, 2001-2010, among 1.3 million women with different lifestyle risk factors for the disease. European Journal of Preventive Cardiology (online first). dx.doi.org/10.1177/2047487314563710

Translational perspective

One of the most striking health achievements of recent decades is the large fall in mortality from vascular diseases, particularly coronary heart disease, but there are signs that this trend may be slowing in some populations.

Despite the knowledge that within populations there is great variation in vascular disease risk factors, there has been limited research into whether, within populations, all groups have benefitted equally from the fall in vascular mortality.

We found evidence that the decline in vascular mortality from 2001-2010 was not uniform across all groups of UK women, including that coronary heart disease mortality declined by nearly three quarters in normal weight women, but only one quarter in obese women.

Continuing reductions in vascular mortality might be achieved by public health or clinical interventions that are better-targeted to the groups which previously have benefitted the least.


EJPC is a European Society for Cardiology journal, and this paper found a home there after being transferred from ESC’s flagship European Heart Journal.  

EHJ includes a “Translational Perspective” with many of its articles, and I wrote one for this study, but EJPC doesn’t do them.  Not to let that effort go to waste, I’ve published it here.

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